Paint.Net has more than just fancy colour palettes. Using multiple effects can create very good looking results, and almost everything that photoshop has can be done by combining Paint.Net's effects. I personally found the effects very useful, as there is great variation, and most of them are complicated algorithms. If you want to make more minor adjustments there is an adjustments car as well.

Paint.Net is easier to use than photoshop, as it's more bare bones. I can just experiment with effects to find fancy combinations.

For instance, my realistic spiderweb texture was made by:
1) rendering clouds in black and white (effects, render, clouds)
2) using the crystallize function ( cell size 85, quality 0) (effects, distort, crystallize)
3) using the bulge function and changing only the bulge amount to -200 (effects, distort, bulge)
4) using the outline function (thickness 6, intensity 35) (effects, stylize, outline)
5 Deleting the white areas (Magic wand tool) (Flood mode: Global) (Tolerance: 0)

In Photoshop it would be very hard to do this, as everything's very cluttered. While this may seem a little complicated, if you try it it's actually quite easy.
(if you find it diffucult to see the cobwebs shape, got to adjustments, invert colors)

In photoshop you'd need a picture of a cobweb to start off with. And perhaps 2000 dollars. Paint.Net is free.

For a texture pack, if you are making something high detail, you should use something like Paint Tool SAI, Photoshop CS6, or Gimp is suggested a lot.

paint.net is the best because its easy and even babies could use it

I use Paint.net for all my skins and blocks, it is simple to use and easy for all ages. Photoshop is for more artistic things, no a Resource Pack. Gimp is also a way to go, but I found Paint.net to be easier!

I ue paint.net u can use transparent prob the best one out there and its free also on complicated.

I'd recommend paint.net I personally found it alot easier than GIMP or the default windows paint

Ooop skype is efc.pb

magic add me on skype it will be worth your time ;D

I personally use GIMP, since I'm too poor for Photoshop..
Gimp works great, though!

It depends on what kind of texture pack you're making. Are you making an hd/realistic pack? Use photoshop/gimp. Are you making a 16x or 32x pack? Definitely use gimp, or photoshop if you know how to use it well. If you're making a texture pack that uses a color palette though, paint.net is the way to go. For me I mainly use gimp because I've found that photoshop is just a bit too unwieldy for normal resolution packs, and gimp has more and easily applied filters and color adjustment options. On my newest project though, I'm using a color palette, which paint.net makes far easier to create, as gimp doesn't allow you to easily and accurately adjust color values to the extent needed for palettes. I hope this helped!