Cruella De Vil is the main antagonist of Disney's 1961 animated feature film 101 Dalmatians. She is an eccentric, fashion-obsessed heiress who wishes to use the skins of 99 Dalmatian puppies to create a spotted fur coat. Regarded as a "witch" and "devil woman", Cruella's infatuation with furs drives her to murderous insanity. She commits immoral acts to satisfy her mania, such as kidnapping and slaughter. In her mad pursuits, Cruella is typically aided by her henchmen, Jasper and Horace.

Cruella first appeared in the novel, The Hundred and One Dalmatians (1956) by Dodie Smith. Perhaps the most famous incarnation of the character was developed for Disney's 1961 animated adaptation One Hundred and One Dalmatians by story man Bill Peet and animator Marc Davis. The Disney villainess proved successful and has led to numerous appearances in other media, most notably the Disney Villains franchise, of which Cruella is a primary member.