General Electric Genesis (officially trademarked GENESIS^[​5]) is a series of passenger diesel locomotives produced by GE Transportation, then a subsidiary of General Electric. Between 1992 and 2001, a total of 321 units were built for Amtrak, Metro-North, and Via Rail.

The Genesis series of locomotives was designed by General Electric in response to a specification published by Amtrak and ultimately selected over a competing design presented by Electro-Motive Diesel (EMD). The Genesis series are the lowest North American diesel-electric locomotives. This height restriction allows the locomotive to travel easily through low-profile tunnels in the Northeast Corridor. The Genesis series is lower than even the previous-generation F40PH by 14 inches (356 mm).