Doc Mitchell was born in Vault 21, where he was known by the nickname "Mole Butt" by the younger residents. He left at some point after it was opened, becoming a traveling doctor to help the people of the wasteland. As Mitchell got older, he returned to New Vegas and married his childhood sweetheart. Some time afterward, he retired to Goodsprings, serving as the town doctor.


His wife, and childhood sweet-heart, died at some point. But he doesn't dwell on the past. If you have visited Vault 21 in New Vegas, and come back to see Doc Mitchell, he will explain that he was going to California with his wife. Due to the weak immune system she had from living in a vault her whole life, she passed away in Goodsprings, causing Doc Mitchell to settle down there so that he could always remain close to her.

In the montage "The Return of Jerry McGhoulBerry" he snaps and steals Jerry McGhoulberry's remains, as revenge for Al putting all his items/mods in his house. When Al confronted Doc Mitchell, Al tried to kill him. However, Doc Mitchell was so powerful that he was able to force Alchestbreach and his crew to flee from the house and fight them outside. Al and his crew summoned the Megazord to battle Doc Mitchell, but Doc Mitchell used his brand new special milk "Doc's new Special Milk" to grow to the same size as the Megazord. After a fierce battle, Doc Mitchell was defeated, exploding and leaving a huge mushroom cloud. Apparently, no one cared about the epic battle that had taken place within Goodsprings.