Cranky's next appearance would be in Donkey Kong 64. Here, Cranky has seemingly taken up science as a hobby; Cranky's Lab can be found in every area of Donkey Kong 64 except Hideout Helm. At Cranky's Lab, the Kongs can pay for several potions that can give them new powers and abilities. Also, if the Kongs manage to collect fifteen Banana Medals, Cranky will allow them to play Jetpac, an early Rare game. The Kongs must beat the Jetpac game in order to obtain the Rareware Coin. Cranky also acts as the Kongs coach during their boxing match against King Krusha K. Rool.


A very little known fact about Cranky's role in DK64 is that it was one of several themes based on the old Donkey Kong Country TV show, in which Cranky was sometimes seen mixing up magic potions to use on either himself or others to advance that episode's plot.