Brain is a genius French scientist and master criminal who exists as a disembodied brain. Trapped forever in his life support chamber, he has extremely little mobility. His partner and lover is a super-intelligent gorilla named Monsieur Mallah. Niles Caulder is his arch-rival, making him an enemy to the Doom Patrol. He is leader of the Brotherhood of Evil, and has also been a member of the Secret Society of Super-Villains.