1. Use the noise feature, it's there for a reason, giving you skins texture makes them look quite a bit better.
2. Try to utilize both layers of the skin, for example on cloaks or hair or things like that
3. I can't stress this one enough, REMEMBER TO COVER ALL SURFACES, this one is very big, always make sure to cover, between the legs, under the head on the inner side of the arms etc. Missing that might not be so noticeable in the editor, but when playing they become really noticeable.