The first production version. Powered by General Electric CF6 or Pratt & Whitney JT9D engines (the same engines that powered the 747 or the DC-10) of between 51,000 and 53,000 lbf (227 and 236 kN) thrust, it entered service with Air France in May 1974. The prototype A300B2 made its first flight on 28 June 1973 and was certificated by the French and German authorities on 15 March 1974 and FAA approval followed on 30 May 1974. The first production A300B2 (A300 number 5) made its maiden flight on 15 April 1974 and was handed over to Air France a few weeks later on 10 May 1974. The A300B2 entered revenue service on 23 May 1974 between Paris and London.

• A300B2-100: 137-tonne (302,000 lb) MTOW
• A300B2-200: 142-tonne (313,000 lb) MTOW, with Krueger flaps, first delivery to South African Airways in 1976
• A300B2-300: increased Maximum Landing Weight/Maximum Zero Fuel Weight