USS Erie (PG-50) was the lead ship of the Erie-class gunboats of the United States Navy. Erie was the second US Navy ship to bear the name. The first, Erie, was named after Lake Erie, while this Erie followed the US Navy naming practices of gunboats, like cruisers, being named after US cities.

Erie protected US interests during the Spanish Civil War, operated as a training ship for the United States Naval Academy, and was a convoy escort ship during World War II. She operated in the Pacific Ocean, Atlantic Ocean, and Caribbean Sea until torpedoed and fatally damaged by U-163, off Curaçao, in 1942.