The film follows Royce (Adrien Brody), a mercenary, who wakes up finding himself falling from the sky into a jungle. Once on the ground, he meets other people who have arrived there in the same manner, all of whom have questionable backgrounds, except for a doctor (Topher Grace). As the film progresses, the group discovers that they are on an alien planet that acts as a game preserve where they are being hunted by a merciless race of aliens known as Predators.