The GE AC4400CW is a 4,400 horsepower (3,300 kW) diesel-electric locomotive that was built by GE Transportation System between 1993 and 2004. It is like the Dash 9-44CW, but features AC traction motors instead of DC, with a separate inverter per motor. In appearance, the AC4400CW is somewhat similar to GE's more powerful locomotive, the AC6000CW.

Over the 11 years in which it was produced, GE constructed 2,834 examples for North American railroads. In 2005, all Class I freight railroads except Norfolk Southern owned at least one AC4400CW. As a result of more stringent emissions requirements that came into effect on January of that year, GE no longer offers the AC4400CW, replacing it with the ES44AC