The Ectomobile, or Ecto-1 is a 1959 Cadillac Miller-Meteor Futura Duplex limo-style endloader combination car (ambulance conversion) used in the 1984 film Ghostbusters and other Ghostbusters fiction. The original vehicle design was the creation of Steven Dane, credited as a Hardware Consultant in the credits.

In the original movie, Stantz pays $4800 (equivalent to $11,812 in 2019) for it and claims it needs a plethora of repairs. In Stantz's own words, it needs "suspension work and shocks, brakes, brake pads, lining, steering box, transmission, rear end... maybe new rings, also mufflers, a little wiring...."

After the necessary reconstruction, it is used to carry the Ghostbusters and their ghost-capturing equipment through New York City. Its features include a special pull-out rack utilizing the old ambulance's gurney in the rear containing the staff's proton packs. There are also various gadgets mounted on the top, whose function is never revealed in the movies. A cartoon episode features the proton cannon, presumably a more powerful version of a proton pack, mounted on top for use against extra-large or even giant-sized paranormal entities.

Earlier versions of scripts written by Aykroyd for the first Ghostbusters also includes mentions of the Ectomobile having the power of interdimensional travel. The shooting script for the movie describes the Ectomobile as being black, with purple and white strobe lights that gave the vehicle a "purple aura".

A miniature replica of the vehicle was mass-produced as a children's toy. Polar Lights released a 1/24 scale model kit of the Ecto-1 in 2002. In 2010, Hot Wheels released a "Ghostbusters Ecto-1" as part of the "2010 Hot Wheels Premiere" series.

Hot Wheels Elite released a highly detailed 1/18 diecast of the Ecto-1 in 2010 and in early 2013, they released a 1/18 Ecto-1A as seen in Ghostbusters II.

The repaired Ectomobile is named on-screen with the license plate shown reading "Ecto-1". The word Ectomobile was only used in the song "Cleaning Up The Town" from the film's soundtrack. The filmmakers planned to have the Ecto-1 painted black, but the color of the vehicle was changed to white when it was decided a black car would be too difficult to see during night scenes. Three cars have played the vehicle in the movies; the third 1959 Miller-Meteor was purchased after the second died during shooting of Ghostbusters II. The black Miller-Meteor seen at the beginning of the first movie was leased and used only for that scene and never converted for filming, though it was later purchased by the studio and completely converted to a full Ecto-1 for touring. Both of the other Ectomobiles are currently sitting in a Sony pictures backlot, having undergone a full restoration after years of deterioration.

Universal Studios "Spooktacular" stage show featured an Ectomobile replica built by a man from Tennessee. The Universal Studios Ecto-1 Replica was sold at the Barrett-Jackson auto auction in Scottsdale Arizona on January 22, 2010 for $80,000. Another replica was made by Peter Mosen and bought by George Barris. Another replica currently resides at Historic Auto Attractions museum in Roscoe, Illinois.