The amygdala appears to be one of the most revered Great Ones as numerous statues of it can be found in the Cathedral Ward and Yahar'gul, Unseen Village. A much larger statue that appears to be part of a shrine is located in the church of the Hypogean Gaol.

Patches the Spider is seemingly one of the most devoted of Amygdala's worshippers and apparently offers sacrifices to his "God" through the use of the Tonsil Stone, transporting them into the Nightmare Frontier. However, should the player slay Amygdala, he expresses no remorse or anger, merely believing they "bestowed salvation" upon the entity.