Hauptstraße 100 in Rheydt was a historicist style early 20th century townhouse located at the end of the middle section of the street Hauptstraße (Main Street) where it connects to the street Limitenstraße.

It was destroyed during the british bombing of Mönchengladbach and Rheydt in 1944.

Next to it was the representative neorenaissance building Hauptstraße 99.